Women Smokers at Risk
Women smokers are three times more likely than men
to get a genetic mutation linked to the worst cases
of cancer. So said a report in the
Journal of the National Cancer Institute.
per cent of lung cancer victims have this mutation,
which makes them four times more likely to die than
other lung cancer victims. Researchers suspect that
the mutation is triggered by the female hormone,
Another study, also reported in the
Journal of the National Cancer Institute,
reports that a gene called GRPR, which is more
active in women than men, could be the reason why
women are more prone to lung cancer than men. The
study, conducted by researchers from the University
of Pittsburgh in the US, involved tests on the lung
tissue from 78 adults (38 women and
men); 58 of the test subjects had been diagnosed
with lung cancer.
It was found that the
peptide receptor" (GRPR) gene, which has been linked
in previous studies with lung cancer, was active in
55% of the non-smoking women, but none of the
non-smoking men showed any signs. At the same time,
75% of the female smokers showed evidence of
activated GRPR (compared to just
of smoking men).
The GRPR gene is carried on the female chromosome
and women have two of them while men only have one.
It is postulated that nicotine activates the GRPR
gene, placing female smokers even more at risk.