Why It's Hard To Lose Weight   

Why It's Hard To Lose Weigh

ONE of the most frustrating mysteries of weight loss is why the weight seem to inevitably pile back on, following a successful diet. Researchers found that being obese can reset "normal" body weight to a permanently elevated level.

Tests in mice found that the longer the animals remained overweight, the more likely their condition would become "irreversible", making it difficult to maintain meaningful weight loss.

Our model demonstrates that obesity is in part a self-perpetuating disorder and the results further emphasize the importance of early intervention in childhood to try to prevent the condition whose effects can last a lifetime.

Mice that remained at a healthy weight into young adulthood by strict dieting alone were able to maintain normal weight without dieting after turning on the switch.

However, chronically overfed mice with the earliest onset of obesity never completely returned to normal weight after flipping the switch, despite marked reduction in food intake and increased activity.


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