to U.S. Researchers, a brain chemical strongly
linked to mood and appetite may also directly affect
levels of serotonin, the
chemical targeted by many antidepressants, may also
direct the body to put down fat regardless of how
much food is eaten..
"It may be
one reason diets fail," said metabolism expert.
The findings, could lead to better
diet drugs and treatments for diseases like
Serotonin may help the body decide
whether to burn off excess calories, or store them
as fat. The findings may relate to humans. These
worm, although they are microscopic, they have
around 20,000 genes ... and if you compare them side
by side they are about 50 percent similar to us.
Genes controlling appetite, fat
storage and metabolism are especially similar, he
said. The tiny worms can be manipulated to see
changes to their metabolism appetite and weight
It has been known for a long time
that increasing serotonin causes fat reduction.
we are trying to
understand what is the mechanism that allows that to
happen. What we discovered in the worm is that those
mechanisms can be separated from the mechanisms that
mediate the effect of serotonin on appetite.
research found serotonin levels affected the worms'
appetite, but they also affected how much fat the
worms accumulated, and this was via a separate
If the worms detect a food
shortage, their metabolisms shift and they store
more fat. This could explain why some people get fat
more easily than others -and why dieting can cause
more weight gain later.
people may have similar diets, may have similar
rates of physical activity, but may have very
different body weights.Appetite
is only part of it. But for now the remedy for
excess body fat remains obvious. Nothing in our
study says that good nutrition and physical activity
are not good for you.
raising serotonin levels can have serious
side-effects. The diet drug fenfluramine, which has
the effect of raising serotonin levels, was pulled
off the market in 1997 after it caused sometimes
deadly heart valve damage.